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The usefulness of cytogentic biomarkers in assessment of occupational exposure to microwave (CROSBI ID 502989)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Garaj-Vrhovac, Vera ; Kopjar, Nevenka The usefulness of cytogentic biomarkers in assessment of occupational exposure to microwave // Environmental and molecular mutagenesis (0893-6692) 3 (2003) ; 62. 2003. str. 62-62-x

Podaci o odgovornosti

Garaj-Vrhovac, Vera ; Kopjar, Nevenka

engleski

The usefulness of cytogentic biomarkers in assessment of occupational exposure to microwave

Cytogentic biomarkers were applied and compared to investigate the genome damage in radar-facility workers daily exposed to microwave radiation and unexposed control subjects. The alkaline comet assay was used to evaluate primary DNA damage, while chromatid breakage assay (bleomicyn sensitivity test) and micronucleus test were used to asswss chromosomal sensitivity and damage. Occupational exposure to microwave radiation correlated with an increase of genome damage in somatoc cells. The overall levels of genome damage in exposed subjects were increased compared to control and showed interindividual variations. The extent of DNA migration was significantly increased in exposed subjects compared to control. After short exposure of cultured lymphocytes to bleomycin, cells of subjects occupationally exposed to microwave radiation responded with high numbers of chromatid breaks. The incidence and distribution of micronuclei in expposed subjects were also changed compared to control Based on the results obtained, cytogenic biomarkers indicate that microwave radiation represents a potential DNA-damaging hazard. It was also confirmed that highly specific cytogenetic assays employed in the present study are hepful to identify occupationally exposed subjects with inborn genetic susceptibuilitzy and point out to the need of implementation of prevevtive measures in decreasing of risk at individual level.

occupational exposure; radar-facility workers; comet assay; chromatid breakage assay; micronucleus test; microwave

nije evidentirano

nije evidentirano

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nije evidentirano

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Podaci o prilogu

62-62-x.

2003.

objavljeno

Podaci o matičnoj publikaciji

Environmental and molecular mutagenesis (0893-6692) 3 (2003) ; 62

Podaci o skupu

Nepoznat skup

poster

29.02.1904-29.02.2096

Povezanost rada

Biologija