engleski

Studies on mixing in horizontal rotating tubular bioreactor. Part II: Prediction systems for adjustable parameters of "spiral flow" model

In previous investigations on mixing in a horizontal rotating tubular bioreactor (HRTB) the structured "spiral flow" model was developed which contained four adjustable parameters. In order to incorporate the mixing model in a semifundamental scale-up procedure it was necessary to make a relation between the adjustable model parameters and process parameters of the bioreactor expressed as dimensionless numbers. Mathematical equations which relate adjustable model parameters with dimensionless numbers were developed by non-linear and surface regression methods. These equations were applied to develop the prediction systems for adjustable model parameters. In total, nine systems of equations for the prediction of the adjustable model parameters were established and examined by simulation. Three of them (SC-2, SC-6 and SC-9) were selected as adequate to describe the mixing performance of HRTB in a wide range of process conditions.

horizontal rotating tubular bioreactor (HRTB); mixing; dimension less numbers; prediction systems

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