engleski

Interrelated effects of high surcose diet and gemfibrozil on buthyrylcholinesterase activity and plasma lipids in rats

Introduction. Butyrylcholinesterase (BuChE), also known as pseudocholinesterase, is produced in the liver and secreted into the circulation. The biological function of BuChE is unknown, but many results show that it is probably involved in serum lipid metabolism. BuChE was found to be elevated in patients with hyper-lipoproteinemia or hypertriglyceridemia, and that streptozotocin- induced diabetic mice have shown increased plasma BuChE activity concomitant with increased plasma triglycerides (TG). Iso-OMPA, a non-toxic inhibitor of plasma BuChE, reduces plasma and liver TG and plasma very-low density lipoproteins (VLDL) in streptozotocin-induced rodent diabetes. Diet rich in sucrose increases the synthesis and secretion of VLDL by the liver and induces hypertriglyceridemia in man and experimental animals. Thus, it could be presumed, that in rats fed with a high carbohydrate diet, the resulting hypertriglyceridemia increases BuChE activity, and that treatment with gemfibrozil (GEM), causes the decrease of plasma TG and BuChE activity.

Buthyrylcholinesterase; triglycerides; gemfibrozil; plasma lipids

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