engleski

Studies on mixing in horizontal rotating tubular bioreactor. Part I: Optimisation of adjustable parameters for "spiral flow" model

A horizontal rotating tubular bioreactor (HRTB) is a combination of a "thin-layer bioreactor" and a "biodisc" reactor. Its interior is divided by O-ring shaped partition walls. Mixing properties of this new type of the bioreactor were investigated by using a temperature step method. The mixing simulations were done by Runge-Kutta-Fehlberg numerical integration. Adjustable parameters of the "spiral flow" model were optimised by Monte-Carlo method. In this investigation, the structured "spiral flow" model (containing four adjustable parameters) was tested in a wide range of experimental conditions. The results show that the structured "spiral flow" model is capable to describe the mixing in HRTB in the whole range of both bioreactor operational parameters (n and D).

horizontal rotating tubular bioreactor (HRTB); mixing spiral flow model optimisation

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