engleski

Effect of Nimodipine on the Brain Free Arachidonic Acid Level in Hypoxia-Exposed Rats

The free fatty acids (FFAs), particularly arachidonic acid, are assumed to have detrimental effects on mitochondrial and plasma membrane functions. Accumulation of the FFAs in the brain in ischemic conditions is a result of theirliberation from membrane phospholipids. The aim of this study was to investigate the effect of nimodipine, calcium channel blocker, on the brain free arachidonic acid level in hypoxia-exposed rats. The study was carried out on Hannover-Wistar rats weighting 250 g. The animals of the control group were intact, drug naive. All other animals were subjected to a period of oxygen deprivation hypoxia. Our results clearly demonstrated that cerebral hypoxia induced progressive increase in the brain arachidonic acid content.The content of the free arachidonic acid did not differ significantly between the animals of the control group and hypoxic nimodipine-treated rats.In Conclusion, our results demontstrated that nimodipine prevented the hypoxia-induced damage.

hypoxia; free arachidonic acid; nimodipine

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