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Pregled bibliografske jedinice broj: 175776

BASIC PHARMACOOLOGICAL ASPECTS OF PAIN ACTING DRUGS


Lacković, Zdravko
BASIC PHARMACOOLOGICAL ASPECTS OF PAIN ACTING DRUGS // Neurologia Croatica. Supplement, 53 (2004), suppl1; 71-75 (podatak o recenziji nije dostupan, pregledni rad, znanstveni)


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Naslov
BASIC PHARMACOOLOGICAL ASPECTS OF PAIN ACTING DRUGS

Autori
Lacković, Zdravko

Izvornik
Neurologia Croatica. Supplement (1331-5196) 53 (2004), Suppl1; 71-75

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
pain; antinociception; anagletic drugs
(pain; antinociception; analgetic drugs)

Sažetak
At the peripheral level, C or A delta fibres are excited by noxious stimuli. Involved molecules are released from cellular lysis, the inflamed surrounding tissues and C or A delta fibres themselves. Recently, molecular biology and genomics have led to the development of new target-selective entities for use in pain relief. A number of receptors and ion channels present in sensory neurons such as tetrodotoxin insensitive Na+ channel, capsaicin-gated i.e. vanilloid receptor 1(VR1), proton-gated or acid-sensing ion channel (ASIC) channels etc. are now under investigation as new potential analgesic drug targets.During pain transmission at the end of the peripheral nerves in the dorsal horn of the spinal cord, the first synapses are modulated by glutamate and many peptides. A lot of supraspinal sites are activated: the brain stem, the pontomesencephalic regions, the thalamic sites and the cortex. Descending inhibitory controls triggered by noxious stimuli probably play an important role too. Currently it is also believed that neuroplasticity plays a crucial role in the onset and maintenance of chronic pain symptoms - including the upregulation of sensory neuron-specific sodium channels and vanilloid receptors, phenotypic switching of large myelinated axons, sprouting within the dorsal horn, and loss of inhibitory neurons due to apoptotic cell death.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0108163

Profili:

Avatar Url Zdravko Lacković (autor)


Citiraj ovu publikaciju:

Lacković, Zdravko
BASIC PHARMACOOLOGICAL ASPECTS OF PAIN ACTING DRUGS // Neurologia Croatica. Supplement, 53 (2004), suppl1; 71-75 (podatak o recenziji nije dostupan, pregledni rad, znanstveni)
Lacković, Z. (2004) BASIC PHARMACOOLOGICAL ASPECTS OF PAIN ACTING DRUGS. Neurologia Croatica. Supplement, 53 (suppl1), 71-75.
@article{article, author = {Lackovi\'{c}, Z.}, year = {2004}, pages = {71-75}, keywords = {pain, antinociception, anagletic drugs}, journal = {Neurologia Croatica. Supplement}, volume = {53}, number = {suppl1}, issn = {1331-5196}, title = {BASIC PHARMACOOLOGICAL ASPECTS OF PAIN ACTING DRUGS}, keyword = {pain, antinociception, anagletic drugs} }
@article{article, author = {Lackovi\'{c}, Z.}, year = {2004}, pages = {71-75}, keywords = {pain, antinociception, analgetic drugs}, journal = {Neurologia Croatica. Supplement}, volume = {53}, number = {suppl1}, issn = {1331-5196}, title = {BASIC PHARMACOOLOGICAL ASPECTS OF PAIN ACTING DRUGS}, keyword = {pain, antinociception, analgetic drugs} }

Uključenost u ostale bibliografske baze podataka::


  • Excerpta Medica
  • Neuroscience Citation Index





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