Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 175618

Vaginal ERT: The Therapeutic Standard for Uro-genital Aging?


Šimunić, Velimir; Ciglar, Srećko; Šprem, Marina
Vaginal ERT: The Therapeutic Standard for Uro-genital Aging? // Fifth International Symposium on Women Health
Firenze, Italy, 2004. (pozvano predavanje, međunarodna recenzija, neobjavljeni rad, znanstveni)


CROSBI ID: 175618 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Vaginal ERT: The Therapeutic Standard for Uro-genital Aging?

Autori
Šimunić, Velimir ; Ciglar, Srećko ; Šprem, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Fifth International Symposium on Women Health

Mjesto i datum
Firenze, Italy, 21.-24.04.2004

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
urogenital atrophy; vaginal ERT

Sažetak
Objective: To determine the efficacy and safety of low dose (25  g) micronized 17  -estradiol administered vaginally in the management of patients with urogenital symptoms. Method: A total of 1612 patients with urogenital complaints were randomized to receive 25  g of micronized 17 -estradiol (828) or placebo (784) in a multicentric double-blind placebo controlled study running for 12 months. The women were treated once a day for two weeks, and then twice a week for the rest of the twelve months with the active or placebo tablet. The assessment included full history-questionnaire, micturition diary, gynecological and cystometric examination, transvaginal ultrasound and serum estradiol level determination. It was carried out at the beginning, and after four and twelve months of treatment. Result: The overall success rate of micronized 17 -estradiol on subjective and objective symptoms of postmenopausal women with vaginal atrophy was 85.5%, and the effect of placebo was 41.4%. A significant improvement of urinary atrophy symptoms was determined in vaginal ERT group comparing with the beginning of the study (51.9% vs. 15.5%, p=0.001). Maximal cystometric capacity and the volume of the urinary bladder at which patients first felt urgency and strong desire to void were considerably larger after micronized 17 -estradiol treatment than before it. The number of patients with uninhibited bladder contractions significantly decreased after micronized 17 -estradiol compared with the values before the treatment or after placebo. Side effects were observed in 61 (7.8%) patients treated with low dose micronized 17- estradiol. We found that 25  g of micronized 17- estradiol do not raise serum estrogen level and do not stimulate endometrial growth. Conclusion: Local administration of 25  g of micronized 17- estradiol is effective and safe treatment option in the management of women with urogenital complaints

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0108259


Citiraj ovu publikaciju

Šimunić, Velimir; Ciglar, Srećko; Šprem, Marina
Vaginal ERT: The Therapeutic Standard for Uro-genital Aging? // Fifth International Symposium on Women Health
Firenze, Italy, 2004. (pozvano predavanje, međunarodna recenzija, neobjavljeni rad, znanstveni)
Šimunić, V., Ciglar, S. & Šprem, M. (2004) Vaginal ERT: The Therapeutic Standard for Uro-genital Aging?. U: Fifth International Symposium on Women Health.
@article{article, year = {2004}, keywords = {urogenital atrophy, vaginal ERT}, title = {Vaginal ERT: The Therapeutic Standard for Uro-genital Aging?}, keyword = {urogenital atrophy, vaginal ERT}, publisherplace = {Firenze, Italy} }
@article{article, year = {2004}, keywords = {urogenital atrophy, vaginal ERT}, title = {Vaginal ERT: The Therapeutic Standard for Uro-genital Aging?}, keyword = {urogenital atrophy, vaginal ERT}, publisherplace = {Firenze, Italy} }




Contrast
Increase Font
Decrease Font
Dyslexic Font