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Pregled bibliografske jedinice broj: 175061

The expression of osteopontin in renal-cell carcinoma


Lučin, Ksenija; Matušan, Koviljka; Đorđević, Gordana, Stipić, Darko
The expression of osteopontin in renal-cell carcinoma // II Intercontinental Congress of Pathology / Soares, Fernando ; Vassallo, Jose ; Bleggi Torres, Luiz F. (ur.).
Bologna: Medimond, 2004. str. 151-154 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


Naslov
The expression of osteopontin in renal-cell carcinoma

Autori
Lučin, Ksenija ; Matušan, Koviljka ; Đorđević, Gordana, Stipić, Darko

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
II Intercontinental Congress of Pathology / Soares, Fernando ; Vassallo, Jose ; Bleggi Torres, Luiz F. - Bologna : Medimond, 2004, 151-154

Skup
Drugi interkontinentalni kongres patologije

Mjesto i datum
Iguassu Falls, Brazil, 9-13.06.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Osteopontin; cell adhesion; prognosis

Sažetak
Osteopontin (OPN)is a phosphoprotein with diverse functions, including cancer development, progression and metastases. In this study, the expression of osteopontin was immunohistochemically assessed in 123 renal-cell carcinomas (RCC) and compared to usual prognostic parameters. The OPN protein was upregulated in 50 RCC (45.5%) of conventional type (CRCC), and this upregulation correlated with tumor size (p<0.05), Fuhrman nuclear grade (p<0.0005) and pathological stage (p<0.01). All papillary RCC showed strong and diffuse cytoplasmic positivity, irrespective of nuclear grade. The collecting duct carcinoma also showed strong and diffuse expression of OPN protein.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0062066

Ustanove
Medicinski fakultet, Rijeka