engleski

Improving of biomonitoring strategy trough collaboration of clinical cytogenetics with genetical toxicology

For the last few decades genetical toxicology has been relying on unstable biomarkers such as chromosome aberrations, micronucleus frequency and sister chromated exchange frequency as indicator of genome damage after exsposure to mutagenic and carcinogenic agents. Although the basic aim of genetical toxicology is to evaluate the risk of cancer development, stable aberrations (translocations, inversions, deletions) critical in carcinogenesis have not been detected due to lack of sutible methods. The collaboration between clinical cytogenetics and genetical toxicology confirms mimportance of translocations.

Clinical cytogenetics; Genetical toxicology

nije evidentirano