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Pregled bibliografske jedinice broj: 17355

The effectiveness of new derivatives of quinuclidinium and imidazolium compounds in soman poisoning


Lucić, Ana; Radić, Božica; Peraica, Maja
The effectiveness of new derivatives of quinuclidinium and imidazolium compounds in soman poisoning // The Book of Abstracts for the Chemical and Biological Medical Treatment Symposium Middle East I / Price, B. (ur.).
Cairo, 1997. (poster, sažetak, znanstveni)


Naslov
The effectiveness of new derivatives of quinuclidinium and imidazolium compounds in soman poisoning
(The effectiveness of new derivatives of quinuclidinium and imidzolium compounds in soman poisoning)

Autori
Lucić, Ana ; Radić, Božica ; Peraica, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The Book of Abstracts for the Chemical and Biological Medical Treatment Symposium Middle East I / Price, B. - Cairo, 1997

Skup
Chemical and Biological Medical Treatment Symposium Middle East I

Mjesto i datum
Kairo, Egipat, 07-11.12.1997.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Neobjavljeni rad

Ključne riječi
Quinuclidinium; imidazolium; soman; oximes; acetylcholinesterase

Sažetak
The efficiency of seven newly synthesized derivatives of quinuclidinium and imidazolium were tested as antidotes in the therapy of soman poisoning. The aim was to compare antidotal activity of compounds containing only monoquinuclidinium or monoimidazolium moiety with compounds containing both moieties in the same molecule. The efficiency of each compund was tested separately in vivi and in vitro. All compouds tested are poor inhibitors of human erythrocyte AChE in vitro. Their in vitro activity as reactivators of soman inhibited AChE, and their protective power against soman inhibition of AChE in vitro are negligible. However, in experiments on mice compounds which contain 3-oxo or 3-carbamoyl substitutent on quinuclidinium (1/4 of their LD 50 dose, i.p.) in combination with atropine sulphate (10 mg/kg b.w., i.p.) gave very good protection against soman (s.c.) intoxication. The therapeutic dose (TD) of these compounds ranged from 2.00 to 4.00 of LD 50 of soman (all animals survived). Compounds which contain only imidazolium moiety or quinuclidinium with hydroxyl group were less effective: their TD was from 1.26 to 1.59 of LD 50 of soman. The highest protective efficiency was seen by use of compound containing 3.carbaoyl substituent on quinuclidinium and oxime group on imidazolium moiety. Tested oximes were synthesized at Faculty of Science University of Zagreb, Strossmayerov trg 14, 10000 Zagreb, Croatia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
00220105

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb