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The effectiveness of new derivatives of quinuclidinium and imidzolium compounds in soman poisoning (CROSBI ID 467442)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Lucić, Ana ; Radić, Božica ; Peraica, Maja The effectiveness of new derivatives of quinuclidinium and imidzolium compounds in soman poisoning // The Book of Abstracts for the Chemical and Biological Medical Treatment Symposium Middle East I / Price, B. (ur.). Kairo, 1997. str. 6-x

Podaci o odgovornosti

Lucić, Ana ; Radić, Božica ; Peraica, Maja

engleski

The effectiveness of new derivatives of quinuclidinium and imidzolium compounds in soman poisoning

The efficiency of seven newly synthesized derivatives of quinuclidinium and imidazolium were tested as antidotes in the therapy of soman poisoning. The aim was to compare antidotal activity of compounds containing only monoquinuclidinium or monoimidazolium moiety with compounds containing both moieties in the same molecule. The efficiency of each compund was tested separately in vivi and in vitro. All compouds tested are poor inhibitors of human erythrocyte AChE in vitro. Their in vitro activity as reactivators of soman inhibited AChE, and their protective power against soman inhibition of AChE in vitro are negligible. However, in experiments on mice compounds which contain 3-oxo or 3-carbamoyl substitutent on quinuclidinium (1/4 of their LD 50 dose, i.p.) in combination with atropine sulphate (10 mg/kg b.w., i.p.) gave very good protection against soman (s.c.) intoxication. The therapeutic dose (TD) of these compounds ranged from 2.00 to 4.00 of LD 50 of soman (all animals survived). Compounds which contain only imidazolium moiety or quinuclidinium with hydroxyl group were less effective: their TD was from 1.26 to 1.59 of LD 50 of soman. The highest protective efficiency was seen by use of compound containing 3.carbaoyl substituent on quinuclidinium and oxime group on imidazolium moiety. Tested oximes were synthesized at Faculty of Science University of Zagreb, Strossmayerov trg 14, 10000 Zagreb, Croatia.

quinuclidinium; imidazolium; soman; oximes; acetylcholinesterase

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Podaci o prilogu

6-x.

1997.

objavljeno

Podaci o matičnoj publikaciji

The Book of Abstracts for the Chemical and Biological Medical Treatment Symposium Middle East I

Price, B.

Kairo:

Podaci o skupu

Chemical and Biological Medical Treatment Symposium Middle East I

poster

07.12.1997-11.12.1997

Kairo, Egipat

Povezanost rada

Kliničke medicinske znanosti