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Palladium(II) complexes of dialkyl alpha-anilinobenzylphosphonates. Synthesis, characterization, and cytostatic activity


Ćurić, Manda; Tušek-Božić, Ljerka; Vikić-Topić, Dražen; Scarcia, Vito; Furlani, Ariella; Balzarini, Jan; De Clercq, Erick
Palladium(II) complexes of dialkyl alpha-anilinobenzylphosphonates. Synthesis, characterization, and cytostatic activity // Journal of inorganic biochemistry, 63 (1996), 2; 125-142 doi:10.1016/0162-0134(95)00199-9 (međunarodna recenzija, članak, znanstveni)


Naslov
Palladium(II) complexes of dialkyl alpha-anilinobenzylphosphonates. Synthesis, characterization, and cytostatic activity

Autori
Ćurić, Manda ; Tušek-Božić, Ljerka ; Vikić-Topić, Dražen ; Scarcia, Vito ; Furlani, Ariella ; Balzarini, Jan ; De Clercq, Erick

Izvornik
Journal of inorganic biochemistry (0162-0134) 63 (1996), 2; 125-142

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Anilinobenzylphosphonates ; palladium(II) complexes ; synthesis ; spectral study ; antitumor activity

Sažetak
The new palladium(II) halide complexes with diethyl and dibutyl esters of (alpha-anilino-N-benzyl)phosphonic acid and diethyl and dibutyl esters of [alpha- (4-benzeneazoanilino)-N-benzyl]phosphonic acid have been prepared and studied. All organophosphorus ligands form dihalide complexes with monodentate N-bonded ligand through the anilinobenzyl nitrogen in (alpha-anilino-N-benzyl)phosphonate complexes and through the azo nitrogen in [alpha-(4-benzeneazoanilino)-N-benzyl]phosphonate complexes, respectively, without participation of the phosphoryl group. Azobenzene containing ligands by ortho-metallation also form binuclear organo-palladium complexes with the metal-metal chloro bridge. The complexes have been identified and characterized by elemental analysis, infrared and proton NMR, as well as by magnetic and conductometric measurements. All were tested in vitro for their cytostatic activity against KB and L1210 tumor cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
00980607

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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