engleski

Monitoring antioxidative ability in patients with traumatic shock

Patients diagnosed with traumatic shock suffer from severe oxidative stress caused by disordered balance between free radicals and antioxidants. The aim of the study was to establish antioxidative ability (ImAnOx) in patients with traumatic shock, and to determine whether supplementation therapy with vitamins E and C lead to improved antioxidative ability in these patients. The first group of patients (N=20) was supplemented with vitamin E (300 IU i.m.) and vitamin C (1000 mg i.v.) once daily during seven days, whereas the second group (N=28) obtained no supplementation therapy. ImAnOx was determined by colorimetric test, Immuno Diagnostik Company, on admission to hospital and on days 1, 3, 7 and 15 of the hospital stay. There was a statistically significant difference on days 3, 7 and 15 (p < 0.0005) between mean ImAnOx concentration values of the two patient groups during the period of observation. Our findings support the conclusion that supplementation therapy with vitamins E and C resulted in enhanced antioxidative ability in patients with traumatic shock.

antioxidative ability; traumatic shock

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