engleski

Differences in calcium metabolism between men with urolithiasis and controls

Investigations in the field of urolithiasis have revealed that the great number of patients with urolithiasis had some metabolic disorder. Stone develop from a wide variety of metabolic or environmental disturbances, including hypercalciuria, hypocitraturia, undue urinary acidity, hyperuricosuria, hyperoxaluria, infection with urease-producing organisms and cystinuria. This paper describes a comprehensive metabolic evaluatian of patients with recurrent stones from eastern part of Croatia. In order to assess possible metabolic disorders in those patients, the healthy contol group was also evaluated. In this study, 26 male patients with urolithiasis (mean age 39.1&plusmn ; 6.2 years) underwent metabolic evaluation. Control group were 18 healthy male subjects (mean age 35.0&plusmn ; 7.1), with no history of stone formation or renal diseases. Biochemical analysis included fasting blood and urine samples, 24-hour and 2-hour urine collections. The most common metabolic abnormalities in patients with urolithiasis were increased levels of urinary oxalate and calcium and uric acid in serum. There were ten patients with hyperoxaluria and six with hypercalciuria. Increased levels of alkaline phosphatase and serum calcium were found in three patients. Parathyroid hormone was inside the reference values in all patients and controls. Our results showed that the most frequent metabolic abnormalities in male patients with urolithiasis, from eastern region of Croatia, were hyperoxaluria and hypercalciuria. However, there were no significant differences in mean values of metabolic parameters between patients and controls. We may conclude that metabolic disorders are important characteristic of urolithiasis, but rarely the single cause of stone formation.

Calcium metabolism; Alkaline phosphatase; Parathyroid hormone; Hypercalciuria; Hyperoxaluria; Metabolic disorders; Urolithiasis; Stones

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