Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 170860

Beta-cell secretory function and CD25+lymphocyte subsets in the early stage of type 1 diabetes mellitus


Miličević, Zvonko; Knežević, Jadranka; Sabioncello, Ante; Roglić, Gojka; Ročić, Boris
Beta-cell secretory function and CD25+lymphocyte subsets in the early stage of type 1 diabetes mellitus // Experimental and clinical endocrinology & diabetes, 112 (2004), 4; 181-186 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 170860 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Beta-cell secretory function and CD25+lymphocyte subsets in the early stage of type 1 diabetes mellitus

Autori
Miličević, Zvonko ; Knežević, Jadranka ; Sabioncello, Ante ; Roglić, Gojka ; Ročić, Boris

Izvornik
Experimental and clinical endocrinology & diabetes (0947-7349) 112 (2004), 4; 181-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
type 1 diabetes; c-peptide; CD25 positive lymphocytes; CD4 positive lymphocytes; CD8 positive lymphocytes

Sažetak
Cellular immunologic tests have not been used for diagnostic purposes in individuals at risk for autoimmune insulitis or in patients with partial beta-cell destruction because of a lack of studies that show their predictive value. In this study we initially evaluated 43 patients with recent-onset Type 1 diabetes (disease duration <or= 6 months, 29 ICA positive) with regard to beta-cell secretion stimulation test with glucagon and immunologic parameters, including CD4 +, CD8 +, CD4 + CD25 +, CD8 + CD25 + lymphocyte subsets. At baseline, C-peptide concentration 6 min after stimulation increased on average by 0.18 +/- 0.27 micro g/ml. The percentage of CD4 + cells was 42 +/- 9, 4 % (healthy controls 44 +/- 7.3 %, p nonsig.) and percentage of CD8 + was 33 +/- 8.6 % (healthy control 31 +/- 8.3 %, p nonsig.). Relative size of CD4 + CD25 + subpopulation was 7 +/- 5.4 % (healthy control 2 +/- 2 %, p < 0.001). Percentage of activated CD8 + cell subset was also increased (2 +/- 1.4 vs. 1.0 +/- 1.0 %), but not significantly. Functional beta-cell testing was repeated after 6 months and nineteen patients were eligible for analysis. Their response was weaker after 6 months (0.13 +/- 0.1 micro g/ml, p < 0.05 vs. baseline). The average change in C-peptide excursion from baseline to the endpoint was - 0.07 +/- 0.17 micro g/ml. There was no significant correlation between beta-cell functional parameters at baseline (C-peptide6min (baseline)) and the relative size of various T cell subpopulations. Results were identical for the 6-month beta-cell functional data (C-peptide6min (6month)). The change in the excursion of C-peptide between baseline and follow-up visit (C-peptide6min (6month-baseline)) showed mild, negative correlation with relative size of the CD8 + CD25 + subpopulation (r = - 0.511, p = 0.025), which may indicate that the size of this cell subpopulation has predictive value in assessing future functional beta-cell changes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0021003
0045001
0021001

Ustanove:
Imunološki zavod d.d.,
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac


Citiraj ovu publikaciju:

Miličević, Zvonko; Knežević, Jadranka; Sabioncello, Ante; Roglić, Gojka; Ročić, Boris
Beta-cell secretory function and CD25+lymphocyte subsets in the early stage of type 1 diabetes mellitus // Experimental and clinical endocrinology & diabetes, 112 (2004), 4; 181-186 (međunarodna recenzija, članak, znanstveni)
Miličević, Z., Knežević, J., Sabioncello, A., Roglić, G. & Ročić, B. (2004) Beta-cell secretory function and CD25+lymphocyte subsets in the early stage of type 1 diabetes mellitus. Experimental and clinical endocrinology & diabetes, 112 (4), 181-186.
@article{article, year = {2004}, pages = {181-186}, keywords = {type 1 diabetes, c-peptide, CD25 positive lymphocytes, CD4 positive lymphocytes, CD8 positive lymphocytes}, journal = {Experimental and clinical endocrinology and diabetes}, volume = {112}, number = {4}, issn = {0947-7349}, title = {Beta-cell secretory function and CD25+lymphocyte subsets in the early stage of type 1 diabetes mellitus}, keyword = {type 1 diabetes, c-peptide, CD25 positive lymphocytes, CD4 positive lymphocytes, CD8 positive lymphocytes} }
@article{article, year = {2004}, pages = {181-186}, keywords = {type 1 diabetes, c-peptide, CD25 positive lymphocytes, CD4 positive lymphocytes, CD8 positive lymphocytes}, journal = {Experimental and clinical endocrinology and diabetes}, volume = {112}, number = {4}, issn = {0947-7349}, title = {Beta-cell secretory function and CD25+lymphocyte subsets in the early stage of type 1 diabetes mellitus}, keyword = {type 1 diabetes, c-peptide, CD25 positive lymphocytes, CD4 positive lymphocytes, CD8 positive lymphocytes} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font