engleski

Transcription factors from Ikaros gene family in human malignancies

Transcription factors from the Ikaros family, Aiolos and Helios, play an essential role in the commitment of hematopoietic progenitors into the lymphoid lineage as well as in the choice of effector functions at later stages of development. Gene targeting studies in mice and also studies of cell populations from leukemic patients indicate that Ikaros, Aiolos and Helios might be involved in leukemogenesis. Therefore we analyzed Aiolos and Helios expression in 8 hematological cell lines, and leukemic cells from 17 patients with morbus Hodgkin’ s and 24 patients with non-Hodgkin’ s lymphoma. Our results show that the pattern of expression of Aiolos and Helios is not homogeneous among different subsets of leukemia.

Ikaros; transcription factors; lymphoid

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