engleski

Antimicrobial susceptibility of nasopharyngeal Streptococcus pneumoniae strains to beta-lactams

The asymptomatic nasopharyngeal carriage of Streptococcus pneumoniae is widely prevalent in children and has been related to the development of disease and the spread of the pathogen.The bacteria carried in the nasopharynx of healthy children reflect the infection-causing strains currently circulating in the community, and so studies of the prevalence of different pathogens and their resistance patterns can provide useful indications for more rational therapeutic and preventive strategies. Present studies have been focused mainly on the incidence of antibiotic-resistant pneumococci among out-patients. S. pneumoniae was isolated from 509/26632 (2%) specimens. From 01.01.2003. till 31.12.2003. the susceptibility of 424 Streptococcus pneumoniae strains to erythromycin, azithromycin, clindamycin, tetracycline, and trimethoprim-sulfamethoxazole was tested using the disk diffusion method. In 86 isolates with reduced sensitivity to penicillin (as determined with oxacillin disk method), minimal inhibitory concentrations (MIC) of penicillin and ceftriaxone was tested by the Etest (AB Biodisk) method. Sensitivity to penicillin was found in 388 (91, 5%) of the 424 Streptococcus pneumoniae while 36 (9, 5%) of the isolates demonstrated decreased susceptibility. Isolates with reduced sensitivity to penicillin had MICs from 0, 12 to 0, 75 jig/ml for penicillin and from 0, 125 to 0, 50 |ug/ml for ceftriaxone. 87 (20, 6%) isolates were resistant to erythromycin and azithromycin, 78 (18, 4%) to clindamycin, 69 (16, 3%) to tetracycline, and 166 (39, 2%) to trimethoprim-sulfamethoxazole.

Streptococcus pneumoniae; susceptibility; beta-lactams

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