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Pregled bibliografske jedinice broj: 168886

Thin chip microsprayer system coupled to quadrupole time-of-flight mass spectrometer for glycoconjugate analysis


Zamfir, Alina; Lion, Niels; Vukelić, Željka; Bindila, Laura; Rossier, Joel; Girault, H. Hubert; Peter-Katalinić, Jasna
Thin chip microsprayer system coupled to quadrupole time-of-flight mass spectrometer for glycoconjugate analysis // Lab on a Chip, 5 (2005), 3; 298-307 (međunarodna recenzija, članak, znanstveni)


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Naslov
Thin chip microsprayer system coupled to quadrupole time-of-flight mass spectrometer for glycoconjugate analysis

Autori
Zamfir, Alina ; Lion, Niels ; Vukelić, Željka ; Bindila, Laura ; Rossier, Joel ; Girault, H. Hubert ; Peter-Katalinić, Jasna

Izvornik
Lab on a Chip (1473-0189) 5 (2005), 3; 298-307

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chip microsprayer system; quadrupole time-of-flight mass spectrometer; glycoconjugates

Sažetak
A thin chip polymer-based microsprayer has been coupled to a hybrid quadrupole time-of-flight mass spectrometer (QTOF MS) and introduced in carbohydrate research. The feasibility of the approach is demonstrated for mapping, sequencing and structural elucidation of glycoconjugates originating from human body fluids and tissues such as a glycopeptide mixture from normal human urine and an isolated and purified GT1 ganglioside fraction from normal adult human brain. The optimization procedure required by each glycoconjugate category is described and the advantages of the system in terms of flexibility and adaptability to QTOF MS, stability of the ESI MS signal, carbohydrate ionization and sequencing, sensitivity, speed of analysis and sample consumption are discussed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0108120

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Željka Vukelić (autor)

Citiraj ovu publikaciju

Zamfir, Alina; Lion, Niels; Vukelić, Željka; Bindila, Laura; Rossier, Joel; Girault, H. Hubert; Peter-Katalinić, Jasna
Thin chip microsprayer system coupled to quadrupole time-of-flight mass spectrometer for glycoconjugate analysis // Lab on a Chip, 5 (2005), 3; 298-307 (međunarodna recenzija, članak, znanstveni)
Zamfir, A., Lion, N., Vukelić, Ž., Bindila, L., Rossier, J., Girault, H. & Peter-Katalinić, J. (2005) Thin chip microsprayer system coupled to quadrupole time-of-flight mass spectrometer for glycoconjugate analysis. Lab on a Chip, 5 (3), 298-307.
@article{article, year = {2005}, pages = {298-307}, keywords = {chip microsprayer system, quadrupole time-of-flight mass spectrometer, glycoconjugates}, journal = {Lab on a Chip}, volume = {5}, number = {3}, issn = {1473-0189}, title = {Thin chip microsprayer system coupled to quadrupole time-of-flight mass spectrometer for glycoconjugate analysis}, keyword = {chip microsprayer system, quadrupole time-of-flight mass spectrometer, glycoconjugates} }
@article{article, year = {2005}, pages = {298-307}, keywords = {chip microsprayer system, quadrupole time-of-flight mass spectrometer, glycoconjugates}, journal = {Lab on a Chip}, volume = {5}, number = {3}, issn = {1473-0189}, title = {Thin chip microsprayer system coupled to quadrupole time-of-flight mass spectrometer for glycoconjugate analysis}, keyword = {chip microsprayer system, quadrupole time-of-flight mass spectrometer, glycoconjugates} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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