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Growth and Biosynthesis of Aflatoxin in the Presence of Newly Synthesized Analogues of Dehydroacetic Acid

The antimycotoxic effect of dehydroacetic acid (DHA) and its newly synthesized analogues, 4-hydroxy-3-(p-toluoyl)-6-(p-tolil)-2H-pyrane-2-one (DHT) and 5-bromo-4-hydroxy-3-(p-toluoyl)-6-(p-tolil)-2H-pyrane-2-one (BrDHT), were tested for antifungal and antiaflatoxigenic activity in experiments with the aflatoxigenic mould Aspergillus flavus ATCC 26949, DHT and DHA concentrations of 2, 0 uM and 4, 0 uM respectively, stimulated mould growth and aflatoxin B1 and G1 synthesis, but concentrations higher than 12, 0 uM produced an inhibitory effect.In the presence of low BrDHT concentrations mould growth decreased by 80% and 90% respectively.

Moulds; mycotoxins; dehydroacetic acid; mould biomass

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