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Preparation and properties of functionalized vesicles as protocell models (CROSBI ID 500702)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Noethig-Laslo, Vesna ; Paleos, Constatinos ; Svetina, Saša ; Šentjurc, Marjeta ; Tomašić, Jelka ; Walde, Peter Preparation and properties of functionalized vesicles as protocell models // 3rd Workshop of the COST Chemistry Action D27 - Prebiotic Chemistry and early Evolution / Pier Luigi Luisi (ur.). Heraklion, 2004. str. 17-x

Podaci o odgovornosti

Noethig-Laslo, Vesna ; Paleos, Constatinos ; Svetina, Saša ; Šentjurc, Marjeta ; Tomašić, Jelka ; Walde, Peter

engleski

Preparation and properties of functionalized vesicles as protocell models

The aim of the research of the working group WG-0006/03 is to prepare functionalized vesicles. Our research will focus on the biophysical properties of vesicles as boundary structures that were possibly relevant in protocellular structures, hypothetical cell-like assemblies that preceeded the first cells. In contemporary cells, a fundamental role of membrane boundaries is to provide a selective permeability barrier that is necessary for separating the cytoplasm from the external environment. Lipid vesicles as models of protocells should have at least similar qualitative permeability characteristics, permitting the diffusion of small molecules into the vesicle and keeping macromolecules trapped inside the vesicle compartments. Furthermore, protocells should form spontaneously and should have fission and fusion properties in order to allow a dynamic evolution of the structure. In our research different conditions will be investigated which could be responsible for the transformation of simple molecular aggregates into vesicles and further to more complex structures which may have led to the formation of protocells. For this purpose we investigate vesicles formed from simple amphiphiles, like fatty acids/soap mixtures, as well as phospholipid vesicles of various composition with respect to: permeability changes (for water and small molecules) in vesicles induced by various conditions which could influence the size, shape and domain structure of the vesicles.

Protocell models; Vesicles; Spin labeling; Pulse EPR; Phospholipid

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Podaci o prilogu

17-x.

2004.

objavljeno

Podaci o matičnoj publikaciji

3rd Workshop of the COST Chemistry Action D27 - Prebiotic Chemistry and early Evolution

Pier Luigi Luisi

Heraklion:

Podaci o skupu

3rd Workshop of the COST Chemistry Action D27 - Prebiotic Chemistry and early Evolution

pozvano predavanje

30.09.2004-03.10.2004

Heraklion, Grčka

Povezanost rada

Kemija, Temeljne medicinske znanosti, Biologija