engleski

Glomerular and tubular disfunction in type II diabetic patients

Recent studies have demonstrated that except glomerular several tubular markers relates to renal complication of diabetes. In present study albumin excretion rate (AER) was considered as a marker of glomerular damage, whereas Tamm-Horsfall protein excretion rate (THPER) as a marker for distal tubular function. Glycosylated hemoglobin (HbA1c) level was used as a measure blood glucose control. Seventy-two patients with NIDDM aged 30-65 years, with diabetes duration of 1-30 years ( 32 males and 42 females ) were included in the study. Correlatin between AER, THPER, disease duration, systolic and diastolic blood pressure and HbA1c level have been studied. Significant rank correlation was found between AER and diastolic blood pressure (R=0.2412, p=0.037) and AER and THPER (R=-3094, p=0.0271) as well a correlation between THPER and disease duration (R=-0.4951, p=0.0002). Significant difference in THPER value between patients with less than fifteen years of disease duration and patients with more than fifteen years disease duration was also found (p<0.0464). In conclusion, these results may indicate a lack of relationship between glomerular and distal tubular dysfunction. As we found the former was influenced by diastolic blood pressure and the latter by disease duration. We can noted the importance of blood pressure regulation in glomerular protection. In contrast to this opservation, tubular dysfunction might progress, despite of blood pressure and glycemia regulation, with longer diabetes duration.

diabetes; albumin excretion; Tamm-Horsfall protein

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