engleski

Doppler ultrasonography date precede albumin excretion rate in diabetic patients

Diabetic nephropathy is a frequent microvascular complication in diabetic patients. Histopathologic changes can be found primarily in the vascular compartement, which can cause the elevation in renal vascular resistence (RVR), manifested by increased value of Doppler renal resistance index (DRRI). Resistance index is one of the most useful and reliable parameters in the spectral flow velocity waveform analysis. Forty-two patients with NIDDM aged 33-65 years , with diabetes duration of the 1-24 years ( 20 males and 22 females ) were included in the study. DRRI was correlated with the duration of diabetes mellitus, systolic and diastolic blood pressure, albumin excretion rate (AER) and Tamm-Horsfall protein excretion rate (THPER). Significant rank correlation was found between the DRRI and the disease duration (R=0.4218, p=0.005), DRRI and the systolic blood pressure (R=0.7544, p=0.000), DRRI and AER (R=0.4217, p=0.005) and DRRI and THPER (R=-0.3264, p=0.055). There was no significant correlation between DRRI and diastolic blood pressure (R=0.2634, p=0.091). The negative correlation between DRRI and THPER can be explained by expected lowerin of THPER with the longer duration of diabetes. These results indicate that kidney Doppler ultrasonography can help to identify ealier stages of diabetic nephropathy. Detection of hypertension, an early consequence of RVR elevation, could precede detection of AER.

diabetes; nephropathy; albumin excretion

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