engleski

The therapy of carbamate and organophosphate intoxication with new oximes

The antidotal effect of bis-imidazolium oxime BDB-122 and quinuclidinium-imidazolium oxime BM-1 was tested in itnoxication with some carbamates and organophosphorus compounds (OPs). Their effectiveness was tested in vitro on human erythrocytes acetylcholinesterase (AChE) and in vivo on mice. Each oxime applied together with atropine had good therapeutic effect in intoxication with carbamates (propoxur, carbaryl, RO-0683) and OPs (dichlorvos and soman). Oxime BDB-122 with atropine protected mice against 16.0 LD50 of propoxur, 2.0 LD50 of carbaryl, 8.0 LD50 of RO2/0683, 22.4 LD50 of dichlorvos, and 2.0 LD50 of soman, whereas oxime BM/1 with atropine yielded a 100 % survival of mice intoxicated with 16.0 LD50 of propxur, 2.5 LD50 of carbaryl, 20.0 LD50 of RO2-0683, 11.5 LD50 of dichlorvos, and 4.0 LD50 of soman. Good therapeutic effect of tested oximes in itnoxication with carbamates is especially interesting, because actually the drug of choice is atropine only.

carbamates; organophosphorus compounds; oximes therapy; acetylcholinesterase

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