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Mitochondrial dysfunction enhances transcription by Gal4 in an Srb10-dependent manner (CROSBI ID 499616)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Traven, Ana ; Jeličić, Branka ; Filić, Vedrana ; Sopta, Mary Mitochondrial dysfunction enhances transcription by Gal4 in an Srb10-dependent manner // Abstracts of the FEBS Lecture Course on Cellular Signaling & 4th Dubrovnik Signaling Conference / Đikić, Ivan ; Husnjak, Koraljka (ur.). Dubrovnik, 2004. str. 56-56

Podaci o odgovornosti

Traven, Ana ; Jeličić, Branka ; Filić, Vedrana ; Sopta, Mary

engleski

Mitochondrial dysfunction enhances transcription by Gal4 in an Srb10-dependent manner

Regulation of gene expression by metabolic pathways is a common strategy used by the cell to adjust to its changing energy requirements. One of the best studied examples of such a mechanism is regulation of galactose-inducible genes by the prototypical acidic activator Gal4. In this report we have analyzed the influence of mitochondrial dysfunction on Gal4 activity and show that respiratory deficient cells increase Gal4-dependent transcription. We show that the DNA-binding and activation domains of Gal4 are sufficient for this effect. Furthermore, the cyclin dependent kinase Srb10 (cdk8) is necessary for mitochondrial signaling to Gal4, but this effect is independent of Gal4 S699 phosphorylation. Mitochondrial dysfunction appears to affect regulation of Gal4 binding to DNA. We suggest that Srb10 dependent phosphorylation of a yet unidentified site, potentially in the Gal4 DNA binding domain, or modification of other transcription factors that cooperate with Gal4 in the process of transcriptional activation underlies the effect of Srb10 on Gal4 transcription in response to mitochondrial dysfunction.

Yeast ; Srb10 ; Gal4 ; mitochondria

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Podaci o prilogu

56-56.

2004.

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objavljeno

Podaci o matičnoj publikaciji

Abstracts of the FEBS Lecture Course on Cellular Signaling & 4th Dubrovnik Signaling Conference

Đikić, Ivan ; Husnjak, Koraljka

Dubrovnik:

Podaci o skupu

Dubrovnik Signaling Conference (4 ; 2004)

predavanje

21.05.2004-27.05.2004

Dubrovnik, Hrvatska

Povezanost rada

Kemijsko inženjerstvo