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The effectiveness of new derivatives of quinuclidinium and imidazolium compounds in tabun poisoning


Lucić, Ana; Radić, Božica; Peraica, Maja
The effectiveness of new derivatives of quinuclidinium and imidazolium compounds in tabun poisoning // Proceedings of the sixth international symposium on protection agains chemical and biological warfare agents
Stockholm: Defence Research Establishment, Div. of NBC Defence, 1998. str. 249-249 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
The effectiveness of new derivatives of quinuclidinium and imidazolium compounds in tabun poisoning

Autori
Lucić, Ana ; Radić, Božica ; Peraica, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the sixth international symposium on protection agains chemical and biological warfare agents / - Stockholm : Defence Research Establishment, Div. of NBC Defence, 1998, 249-249

Skup
Sixth International Symposium on Protection against Chemical and Biological Warfare Agents

Mjesto i datum
Štokholm, Švedska, 10-15.05.1998.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Oximes; tabun; quinuclidinium; imidazolium

Sažetak
Therapeutic efficacy of standard oximes (PAM, HI-6, Obidoxime) with atropine in poisoning with highly toxic organophosphorus compounds such as nerve agents (soman, sarin, tabun, VX) is not satisfactory, especially in case of soman or tabun intoxication. Therefore, the problem of a universal antidote remains open and the search for new antidotes is important from the practical point of view. In this paper derivatives of quinuclidinium and imidazolium, previously tested as antidotes in the therapy of soman poisoning, were also tested in tabun intoxication. Therapeutic effect of these compounds was tested on male mice and expressed as therapeutic dose and therapeutic factor. All tested compounds were applied intraperitoneally (1/4 of their respective LD50 dose) together with atropine sulphate (10 mg/kg b.w.) one minute after subcutaneous administration of tabun. Compounds which contain 3-carbamoyl substituent on quinuclidinium ring, or dioxime which contain two imidazolium rings, gave very good protection against tabun intoxication. Therapeutic dose (all animals survived) was 2.5-4.0 LD50 of tabun and therapeutic factor 3.2-4.3 LD50 of tabun. Compounds which contain only imidazolium ring, quinuclidinium ring with 3-hydroxy or 3-oxo group and both rings with 3-hydroxy group on quinuclidinium were less effective against tabun poisoning. Therefore, the same group of compounds that gave good therapeutic effect against soman poisoning, gives very good antidotal activity in tabun poisoning also. The best effect was obtained by use of the compounds containing carbamoyl group, and therefore it seems that carbamoyl group as substituent on quinuclidinium ring contributes to the antidotal effectiveness in the therapy of soman and tabun poisoning. All tested compounds were synthesised at Faculty of Science, University of Zagreb.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
00220105

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb