Napredna pretraga

Pregled bibliografske jedinice broj: 159883

Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss- and ds- polynucleotides


Piantanida, Ivo; Palm, Barbara S.; Čudić, Predrag; Žinić, Mladen; Schneider, Hans-Jorg
Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss- and ds- polynucleotides // Tetrahedron, 60 (2004), 6225-6231 (međunarodna recenzija, članak, znanstveni)


Naslov
Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss- and ds- polynucleotides

Autori
Piantanida, Ivo ; Palm, Barbara S. ; Čudić, Predrag ; Žinić, Mladen ; Schneider, Hans-Jorg

Izvornik
Tetrahedron (0040-4020) 60 (2004); 6225-6231

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bis-phenanthridinium; Intercalation; DNA; RNA.

Sažetak
The acyclic bis-phenanthridinium ligands 1, 2 and the cyclic analogue 3 bind to ss-RNA by bis-intercalation. Due to it's shorter linker 1 exhibits mono-intercalative binding to ds-polynucleotides, while a mixed mode of binding with 2 is shown to strongly dependent on the base composition and tertiary structure of ds-DNA and RNA. The cyclic analogue 3 binds to ds-polynucleotides by non-intercalative mode. Comparing the ss-/ds-polynucleotide selectivity obtained for 3 and previously reported for 3, 8-linked bis-phenanthridinium analogues, it is clear that the more rigid structure and sterically more restricted cleft of the latter could better distinguish ss- from ds-polynucleotide regions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098053

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • Biological Abstracts
  • Chemical Abstracts