The effectiveness of new derivatives of quinuclidinium and imidazolium compounds in tabun poisoning (CROSBI ID 467113)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Lucić, Ana ; Radić, Božica ; Peraica, Maja
engleski
The effectiveness of new derivatives of quinuclidinium and imidazolium compounds in tabun poisoning
Therapeutic efficacy of standard oximes (PAM, HI-6, Obidoxime) with atropine in poisoning with highly toxic organophosphorus compounds such as nerve agents (soman, sarin, tabun, VX) is not satisfactory, especially in case of soman or tabun intoxication. Therefore, the problem of a universal antidote remains open and the search for new antidotes is important from the practical point of view. In this paper derivatives of quinuclidinium and imidazolium, previously tested as antidotes in the therapy of soman poisoning, were also tested in tabun intoxication. Therapeutic effect of these compounds was tested on male mice and expressed as therapeutic dose and therapeutic factor. All tested compounds were applied intraperitoneally (1/4 of their respective LD50 dose) together with atropine sulphate (10 mg/kg b.w.) one minute after subcutaneous administration of tabun. Compounds which contain 3-carbamoyl substituent on quinuclidinium ring, or dioxime which contain two imidazolium rings, gave very good protection against tabun intoxication. Therapeutic dose (all animals survived) was 2.5-4.0 LD50 of tabun and therapeutic factor 3.2-4.3 LD50 of tabun. Compounds which contain only imidazolium ring, quinuclidinium ring with 3-hydroxy or 3-oxo group and both rings with 3-hydroxy group on quinuclidinium were less effective against tabun poisoning. Therefore, the same group of compounds that gave good therapeutic effect against soman poisoning, gives very good antidotal activity in tabun poisoning also. The best effect was obtained by use of the compounds containing carbamoyl group, and therefore it seems that carbamoyl group as substituent on quinuclidinium ring contributes to the antidotal effectiveness in the therapy of soman and tabun poisoning. All tested compounds were synthesised at Faculty of Science, University of Zagreb.
oximes; tabun; quinuclidinium; imidazolium
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Podaci o prilogu
249-249-x.
1998.
objavljeno
Podaci o matičnoj publikaciji
Stockholm: Defence Research Establishment, Div. of NBC Defence
Podaci o skupu
Sixth International Symposium on Protection against Chemical and Biological Warfare Agents
poster
10.05.1998-15.05.1998
Stockholm, Švedska