engleski

Elevated Second-trimester Free beta-hCG as an Isolated Finding and Pregnancy Outcomes

Objective: To investigate the relationship between unexplained elevated second-trimester free ß -human chorionic gonadotropin (free b-hCG) levels and pregnancy complications as well as adverse pregnancy outcomes. Methods: The study cohort comprised 2, 110 non-smoking women with chromosomal and structurally normal fetuses at low-risk for both Down's syndrome (risk <1:250) and neural tube defects (maternal serum alphafetoprotein ł2.0 MoM). A free ß -hCG value of ł2.0 MoM was used to define the populations with elevated levels of free ß-hCG. Descriptive statistics, hi2 test, Fisher's exact test, and logistic regression analysis were used for statistical analysis, and p !0.05 was considered statistically significant. Results: The mean maternal age of the study group was significantly lower than in controls (27.9&plusmn ; 4.3 and 30.6 &plusmn ; 5.1 years, respectively, p<0.05), while the proportion of primigravidas was significantly higher compared to that of controls (p< 0.05). After adjustment of the 2 groups according to maternal age and parity, we observed an increased incidence of preeclampsia among women with elevated free ß -hCG levels in relation to controls (p<0.05). However, a logistic regression analysis demonstrated that the free ß -hCG level was not a predictor of the occurrence of preeclampsia. No significant relationship was found with the incidence of gestational diabetes, oligohydramnios, polyhydramnios pregnancy-related hypertension, intrauterine growth retardation, preterm delivery, spontaneous abortion and stillbirths (p<0.05).

beta-human chorionic gonatotropin; Pregnancy complications; Pregnancy outcomes

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