engleski

Interleukin-6, transforming growth factor-beta 1, and bone markers after kidney transplantation.

The aim was to investigate the relationship between interleukin 6 (IL-6), transforming growth factor (TGF)-beta, IL-6 soluble receptors and biochemical parameters of bone turnover after kidney transplantation. Out of 64 patients enrolled in the study, 19 received the kidney transplant 2-12 months before the study and 45 within the previous 15-175 months. We measured IL-6, TGF-beta 1, intact PTH, bone alkaline phosphatase (BALP), osteocalcin (OC), and procollagen type I propeptide (P1CP) in the serum and deoxypyridinoline crosslinks (DPD) in the urine of the patients. In 16 patients in the first post-transplantation year, the concentrations of IL-6 (P = 0.02), TGF-beta 1 (P = 0.01), BALP (P = 0.0002), OC (P = 0.001), and DPD (P = 0.01) were significantly higher. Statistically significant negative correlation was found between post-transplantation time and IL-6 (P = 0.04), BALP (P = 0.003), OC (P = 0.0009), P1CP (P = 0.03), and DPD (P = 0.01). Repeated measurements of the investigated parameters in the first post-transplantation year showed a significant decrease only in TGF-beta 1. In all patients, IL-6 correlated positively with PTH (P = 0.0009) and DPD (P = 0.03), and IL-6sR with DPD (P = 0.03). A decrease in IL-6 and TGF-beta 1 that paralleled the decrease in bone turnover markers in the post-transplantation period indicated that IL-6 and TGF-beta 1 were probably involved in the bone turnover after kidney transplantation.

bone markers; interleukin-6; kidney transplantation; transforming growth factor-beta

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