Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Perforin expression in peripheral blood lymphocytes and skin-infiltrating cells in patients with lichen planus (CROSBI ID 107541)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Prpić Massari, Larisa ; Kaštelan, Marija ; Gruber, Franjo ; Laškarin, Gordana ; Sotošek Tokmadžić, Vlatka ; Štrbo, Nataša ; Zamolo, Gordana ; Žauhar, Gordana ; Rukavina, Daniel Perforin expression in peripheral blood lymphocytes and skin-infiltrating cells in patients with lichen planus // British journal of dermatology, 151 (2004), 2; 433-439. doi: 10.1111/j.1365-2133.2004.06086.x

Podaci o odgovornosti

Prpić Massari, Larisa ; Kaštelan, Marija ; Gruber, Franjo ; Laškarin, Gordana ; Sotošek Tokmadžić, Vlatka ; Štrbo, Nataša ; Zamolo, Gordana ; Žauhar, Gordana ; Rukavina, Daniel

engleski

Perforin expression in peripheral blood lymphocytes and skin-infiltrating cells in patients with lichen planus

Current evidence suggests that lichen planus is a T-cell-mediated autoimmune disease in which cytotoxic mechanisms have been poorly investigated. We investigated the expression of perforin in subpopulations of peripheral blood lymphocytes (PBL) in exacerbation and remission phases of the disease as well as in skin lesions. We performed a simultaneous detection of perforin (intracellular molecule) and cell surface antigens on PBL by flow cytometry, and skin lesions were investigated by immunohistochemistry. The most interesting finding was a significant increase of perforin expression in cytotoxic T lymphocytes (CD3+ perforin+ cells) in the exacerbation phase of disease (P < 0.05), which was mostly located in the CD8+ subpopulation (CD8+ perforin+) (P < 0.01). Using immunohistochemistry we confirmed the infiltration of T lymphocytes in skin lesions, especially of CD4+ and CD8+ phenotypes, compared with uninvolved (P < 0.05) and healthy skin (P < 0.01). The expression of perforin was also significantly higher in lesional skin compared with nonlesional and healthy skin (P < 0.05). Our results clearly show the upregulation of perforin expression in peripheral blood as well as in lesions of patients with lichen planus and therefore suggest an important role for perforin in this autoimmune disease.

cytotoxic T lymphocytes; Lichen planus; natural killer cells; perforin

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

151 (2)

2004.

433-439

objavljeno

0007-0963

10.1111/j.1365-2133.2004.06086.x

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost