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Pregled bibliografske jedinice broj: 15884

Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment


Kurelec, Branko; Britvić, Smiljana; Pivčević, Branka; Smital, Tvrtko
Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment // Marine environmental research, 46 (1998), 1-5; 415-419 doi:10.1016/S0141-1136(97)00065-2 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 15884 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment

Autori
Kurelec, Branko ; Britvić, Smiljana ; Pivčević, Branka ; Smital, Tvrtko

Izvornik
Marine environmental research (0141-1136) 46 (1998), 1-5; 415-419

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
p-glycoprotein; mechanism; cells

Sažetak
The protective function of multixenobiotic resistance (MXR) mechanism in aquatic organisms can be inhibited by many chemical compounds, the chemosensitizers. The presence of these MXR-inhibitors has important implications on environmental parameters like exposure, uptake, internal dose, bioaccumulation, response, synergism or toxicity, enhancing thereby the complexity of assessment of risks caused by pollution. The concentration of MXR-inhibitors was significantly higher in samples of water concentrates, sediment extracts, and native waters from polluted marine sites, or from polluted rivers, than in samples from corresponding unpolluted sites. In this paper we demonstrate that even nontoxic lipophilic agents from house-hold waste or from communal waste-waters may be recognised and processed by this molecular mechanism, and, at high concentrations, might saturate the system and thereby reverse MXR. These findings stress why it is important not to burden the environment unnecessary with our waste: it is better to save the capacity of the MXR for pumping out toxic substances, natural or artificial. The discovery of MXR and the identification of a new class of hazardous chemical, the chemosensitizers, offer a scientific proof for the necessity of the zero-emission strategy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
00981510

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Kurelec, Branko; Britvić, Smiljana; Pivčević, Branka; Smital, Tvrtko
Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment // Marine environmental research, 46 (1998), 1-5; 415-419 doi:10.1016/S0141-1136(97)00065-2 (međunarodna recenzija, članak, znanstveni)
Kurelec, B., Britvić, S., Pivčević, B. & Smital, T. (1998) Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment. Marine environmental research, 46 (1-5), 415-419 doi:10.1016/S0141-1136(97)00065-2.
@article{article, year = {1998}, pages = {415-419}, DOI = {10.1016/S0141-1136(97)00065-2}, keywords = {p-glycoprotein, mechanism, cells}, journal = {Marine environmental research}, doi = {10.1016/S0141-1136(97)00065-2}, volume = {46}, number = {1-5}, issn = {0141-1136}, title = {Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment}, keyword = {p-glycoprotein, mechanism, cells} }
@article{article, year = {1998}, pages = {415-419}, DOI = {10.1016/S0141-1136(97)00065-2}, keywords = {p-glycoprotein, mechanism, cells}, journal = {Marine environmental research}, doi = {10.1016/S0141-1136(97)00065-2}, volume = {46}, number = {1-5}, issn = {0141-1136}, title = {Fragility of multixenobiotic resistance in aquatic organisms enhances the complexity of risk assessment}, keyword = {p-glycoprotein, mechanism, cells} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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