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Pregled bibliografske jedinice broj: 158511

Probabilistic kinetic model of slow oxidation of LDL. II. Experiments


Krilov, Dubravka; Stojanović, Nataša; Herak, Janko N.
Probabilistic kinetic model of slow oxidation of LDL. II. Experiments // Chemistry and physics of lipids, 129 (2004), 75-84 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 158511 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Probabilistic kinetic model of slow oxidation of LDL. II. Experiments

Autori
Krilov, Dubravka ; Stojanović, Nataša ; Herak, Janko N.

Izvornik
Chemistry and physics of lipids (0009-3084) 129 (2004); 75-84

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
alpha-tocopherol; prooxidant; atherosclerosis; LDL; oxidation; peroxidation kinetics; tocopherol-mediated peroxidation

Sažetak
Theoretical probabilistic kinetic model has been applied to describe the measurements of several oxidation markers as a function of time, during slow oxidation of low-density lipoprotein (LDL). It has been demonstrated that such a process could be described as tocopherol-mediated peroxidation (TMP), initiated and sustained by the action of copper ions, present in LDL in trace amounts. In that process concentration of  -tocopherol remains essentially unaltered. Tocopherol and copper ions act as catalysts, oscillating between the oxidized and reduced states. The fitting of the theoretical model to the experimental data resulted in determination of the numerical values for the kinetic parameters. It has been found that the parameter values used for the fitting of the data collected for a number of samples from various donors differ rather little. The kinetic chain length of 1.3 (in presence of co-antioxidants) and 2.9 (in the absence of co-antioxidants) is shorter than found by others. The difference probably comes from the much lower concentration of copper ions in our systems (about 0.1 ion per LDL particle).

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA


Projekti:
0006421

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Janko Herak (autor)

Avatar Url Nataša Stojanović (autor)

Avatar Url Dubravka Krilov (autor)


Citiraj ovu publikaciju:

Krilov, Dubravka; Stojanović, Nataša; Herak, Janko N.
Probabilistic kinetic model of slow oxidation of LDL. II. Experiments // Chemistry and physics of lipids, 129 (2004), 75-84 (međunarodna recenzija, članak, znanstveni)
Krilov, D., Stojanović, N. & Herak, J. (2004) Probabilistic kinetic model of slow oxidation of LDL. II. Experiments. Chemistry and physics of lipids, 129, 75-84.
@article{article, year = {2004}, pages = {75-84}, keywords = {alpha-tocopherol, prooxidant, atherosclerosis, LDL, oxidation, peroxidation kinetics, tocopherol-mediated peroxidation}, journal = {Chemistry and physics of lipids}, volume = {129}, issn = {0009-3084}, title = {Probabilistic kinetic model of slow oxidation of LDL. II. Experiments}, keyword = {alpha-tocopherol, prooxidant, atherosclerosis, LDL, oxidation, peroxidation kinetics, tocopherol-mediated peroxidation} }
@article{article, year = {2004}, pages = {75-84}, keywords = {alpha-tocopherol, prooxidant, atherosclerosis, LDL, oxidation, peroxidation kinetics, tocopherol-mediated peroxidation}, journal = {Chemistry and physics of lipids}, volume = {129}, issn = {0009-3084}, title = {Probabilistic kinetic model of slow oxidation of LDL. II. Experiments}, keyword = {alpha-tocopherol, prooxidant, atherosclerosis, LDL, oxidation, peroxidation kinetics, tocopherol-mediated peroxidation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • Biological Abstracts
  • Chemical Abstracts





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