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Pregled bibliografske jedinice broj: 158477

Probabilistic kinetic model of slow oxidation of LDL. I. Theory


Herak, Janko N.; Stojanović, Nataša; Krilov, Dubravka
Probabilistic kinetic model of slow oxidation of LDL. I. Theory // Chemistry and physics of lipids, 129 (2004), 63-74 (međunarodna recenzija, članak, znanstveni)


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Naslov
Probabilistic kinetic model of slow oxidation of LDL. I. Theory

Autori
Herak, Janko N. ; Stojanović, Nataša ; Krilov, Dubravka

Izvornik
Chemistry and physics of lipids (0009-3084) 129 (2004); 63-74

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
alpha-tocopherol; prooxidant; atherosclerosis; LDL; oxidation; peroxidation kinetics; tocopherol-mediated peroxidation

Sažetak
The microscopic probabilistic model has been introduced to explain the kinetics of very slow oxidation of low-density lipoprotein (LDL) from human plasma. The LDL oxidation, carried out in very unfavorable conditions, is assumed to be initiated by the traces of the transition-metal ions associated with the lipoprotein. The substrates for the metal-ion attack are  -tocopherol and the pre-formed lipid hydroperoxide. The theory assumes oscillation of the metal ions and  -tocopherol from the oxidized to the reduced states. In this model  -tocopherol acts as a pro-oxidant. The entire oxidation process consists of rare bursts of events in individual LDL particles. The reactions within the particles are treated in terms of probabilities of individual active species to participate in a specified reaction. The circular flow of the radical reactions could be visualized as circular flow of microscopic probabilities. The empirical, macroscopic quantities are quantitatively related with the microscopic probabilities, determined by a set of five adjustable parameters. The differential equations describing the initial radical generation rate and the rates of change of concentration of oxygen, hydroperoxide, co-antioxidant and trapped radicals in an LDL system are numerically solved in a finite difference approach.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biologija



POVEZANOST RADA


Projekti:
0006421

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Janko Herak (autor)

Avatar Url Nataša Stojanović (autor)

Avatar Url Dubravka Krilov (autor)


Citiraj ovu publikaciju:

Herak, Janko N.; Stojanović, Nataša; Krilov, Dubravka
Probabilistic kinetic model of slow oxidation of LDL. I. Theory // Chemistry and physics of lipids, 129 (2004), 63-74 (međunarodna recenzija, članak, znanstveni)
Herak, J., Stojanović, N. & Krilov, D. (2004) Probabilistic kinetic model of slow oxidation of LDL. I. Theory. Chemistry and physics of lipids, 129, 63-74.
@article{article, year = {2004}, pages = {63-74}, keywords = {alpha-tocopherol, prooxidant, atherosclerosis, LDL, oxidation, peroxidation kinetics, tocopherol-mediated peroxidation}, journal = {Chemistry and physics of lipids}, volume = {129}, issn = {0009-3084}, title = {Probabilistic kinetic model of slow oxidation of LDL. I. Theory}, keyword = {alpha-tocopherol, prooxidant, atherosclerosis, LDL, oxidation, peroxidation kinetics, tocopherol-mediated peroxidation} }
@article{article, year = {2004}, pages = {63-74}, keywords = {alpha-tocopherol, prooxidant, atherosclerosis, LDL, oxidation, peroxidation kinetics, tocopherol-mediated peroxidation}, journal = {Chemistry and physics of lipids}, volume = {129}, issn = {0009-3084}, title = {Probabilistic kinetic model of slow oxidation of LDL. I. Theory}, keyword = {alpha-tocopherol, prooxidant, atherosclerosis, LDL, oxidation, peroxidation kinetics, tocopherol-mediated peroxidation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • Biological Abstracts
  • Chemical Abstracts





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