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The Dissociation Constants of 1, 1'-Bis(pyridinium-4-aldoxime)trimethylene dibromide

The dissociation constants of the two oxime groups of 1, 1'-bis(pyridinium-4-aldoxime)trimethylene dibromide (TMB-4) were determined using spectrophotometric data. Two numerical methods were applied to treat the overlapping equilibria. The results obtained by both agreed with each other and their mean values at 25 C corrected for the ionic strength of 0.05 mol/L are pKa1=7.49+/-0.11 and pKa2=8.96+/-0.09. These values were discussed in terms of the pKas of 1, 1'-bis(pyridinium-4-aldoxime)oxydimethylene dichloride (Toxogonin), a similar dioxime, which were derived by extrapolation of literature data.

1; 1'-Bis(pyridinium-4-aldoxime)trimethylene dibromide; Dissociation constants; Spectrophotometry;

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