engleski

Cholinesterase Unit: the importance of identification of carriers of inherited serum butyrylcholinesterase variants

Recognition of butyrylcholinesterase (EC 3.1.1.8) variants in human serum is essential to identify patients who may be susceptible to a prolonged reaction of suxamethonium, a short-acting muscle relaxant. Thus they can be given appropriate advice along with any relatives who may be similarly affected. Therefore, Cholinesterase Unit for detection of individuals, carriers of inherited suxamethonium sensitive butyrylcholinesterase variants has been initiated in the Institute for Clinical Chemistry at the Clinical Hospital Merkur, Zagreb, Croatia. Butyrylcholinesterase variants were determined by measuring the enzyme catalytic activity and inhibition by specific inhibitors in sera of 384 patients and of members of seven families. Cholinesterase Unit established "Warning Cards" and issued them to the carriers of inherited serum butyrylcholinesterase variants in order to avoid prolonged respiratory apnea that short acting muscle relaxants (suxamethonium, mivacurium) might cause.

butyrylcholinesterase; human serum variants; suxamethonium; phenotypes

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