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Liposomal gels for vaginal drug delivery


Pavelić, Željka; Škalko-Basnet, Nataša; Schubert, Rolf; Jalšenjak, Ivan
Liposomal gels for vaginal drug delivery // Methods in Enzymology / Duzgunes, Nejat (ur.).
San Diego: Elsevier Academic Press, 2004. str. 287-299


Naslov
Liposomal gels for vaginal drug delivery

Autori
Pavelić, Željka ; Škalko-Basnet, Nataša ; Schubert, Rolf ; Jalšenjak, Ivan

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Methods in Enzymology

Urednik/ci
Duzgunes, Nejat

Izdavač
Elsevier Academic Press

Grad
San Diego

Godina
2004

Raspon stranica
287-299

ISBN
0-12-182792-5

Ključne riječi
Liposomes, vaginal drug delivery, hydrogel, bioadhesive
(Iposomes, vaginal drug delivery, hydrogel, bioadhesive)

Sažetak
Chapter describes development of a liposomal vaginal drug carrier system for vaginal delivery capable to provide sustained and controlled release of entrapped drug. Liposomes containing hydrophilic model substances were prepared by methods that yield high trapping efficiency and tested for in vitro stability in different media that mimic human vaginal conditions (buffer, pH 4.5 ; vaginal fluid simulant with or without mucin). Incorporation of liposomes in Carbopol gels further improved their stabilty. Characterisation of liposomal gel, based on investigation of their flow behaviour and determination of physical stability during storage at stress conditions, confirmed appropriate viscosity and physical stability of liposomes in gels. All performed experiments in this study have proven applicability of liposomes incorporated in gel as a novel vaginal delivery system for localised and sustained release of entrapped substances.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekt / tema
0006561

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb