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Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma


Levanat, Sonja; Musani, Vesna; Komar, Arijana; Orešković, Slavko
Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma // Annals of the New York Academy of Sciences, 1031 (2004), 134-143 (međunarodna recenzija, članak, znanstveni)


Naslov
Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma

Autori
Levanat, Sonja ; Musani, Vesna ; Komar, Arijana ; Orešković, Slavko

Izvornik
Annals of the New York Academy of Sciences (0077-8923) 1031 (2004); 134-143

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hedgehog/patched signaling; SHH; SMO; GLI1; PTCH; PTCH polymorphisms; ovarian fibromas; ovarian dermoids

Sažetak
We compared the expression of target genes of Hedgehog/patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of heterozygosity findings in the PTCH locus and increased expression of several genes in the pathway strongly suggest that the pathway is involved in both ovarian fibromas and dermoids.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0098091
0108116

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Sonja Levanat (autor)

Avatar Url Slavko Orešković (autor)

Avatar Url Vesna Musani (autor)

Avatar Url Arijana Zorić (autor)

Citiraj ovu publikaciju

Levanat, Sonja; Musani, Vesna; Komar, Arijana; Orešković, Slavko
Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma // Annals of the New York Academy of Sciences, 1031 (2004), 134-143 (međunarodna recenzija, članak, znanstveni)
Levanat, S., Musani, V., Komar, A. & Orešković, S. (2004) Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma. Annals of the New York Academy of Sciences, 1031, 134-143.
@article{article, year = {2004}, pages = {134-143}, keywords = {Hedgehog/patched signaling, SHH, SMO, GLI1, PTCH, PTCH polymorphisms, ovarian fibromas, ovarian dermoids}, journal = {Annals of the New York Academy of Sciences}, volume = {1031}, issn = {0077-8923}, title = {Role of the Hedgehog/Patched signaling pathway in oncogenesis. A new polymorphism in the PTCH gene in ovarian fibroma}, keyword = {Hedgehog/patched signaling, SHH, SMO, GLI1, PTCH, PTCH polymorphisms, ovarian fibromas, ovarian dermoids} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE