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Pregled bibliografske jedinice broj: 155829

Experimental campylobacteriosis in C57Bl/6 mice


Vučković, Darinka; Abram, Maja; Dorić, Miljenko
Experimental campylobacteriosis in C57Bl/6 mice // Zbornik / Balenović, Mirta ; Wittner, Velimir (ur.).
Zagreb: Hrvatsko mikrobiološko društvo, 2004. (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 155829 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Experimental campylobacteriosis in C57Bl/6 mice

Autori
Vučković, Darinka ; Abram, Maja ; Dorić, Miljenko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik / Balenović, Mirta ; Wittner, Velimir - Zagreb : Hrvatsko mikrobiološko društvo, 2004

Skup
Treći hrvatski mikrobiološki kongres s međunarodnim sudjelovanjem

Mjesto i datum
Poreč, Hrvatska, 4.-7.10.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Campylobacter; mice; experimental

Sažetak
Campylobacter jejuni is, today, recognized as one of the most frequently reported cause of acute inflammatory gastroenteritis in man. Because the lack of appropriate animal model the mechanisms involved in the pathogenesis and immunological response of the host to campylobacteriosis are still poorly understood. In this study, on the established experimental model of murine campylobacteriosis, we investigated the role of T lymphocytes and NK cells in the course of primary C. jejuni infection. We enumerated bacteria in the livers and spleens of challanged control and mice which were, in vivo, depleted of either CD4+, CD8+ or NK cells by intraperitoneal administration of appropriate monoclonal antibodies (mAb). In the immunocompetent animals the sterile clearance of bacteria from their spleens was achieved ten days and from the livers two weeks after infection. Results after in vivo administration of anti-CD4 mAb, anti-CD8 mAb or anti-NK 1.1.+ mAb showed that mice remained capable of resolving primary C. jejuni infection, but the duration was prolonged and bacterial titres were significantlly higher in livers, especially in the case of NK cells depletion. Lack of CD8+ lymphocytes and NK cells prolonged the course and increased the number of C. jejuni in the spleen of infected mice. The results show that cellular immunity may play a role in host defence against C. jejuni what has to be futher elucidated.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0062023

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Miljenko Dorić (autor)

Avatar Url Darinka Vučković (autor)

Avatar Url Maja Abram (autor)


Citiraj ovu publikaciju:

Vučković, Darinka; Abram, Maja; Dorić, Miljenko
Experimental campylobacteriosis in C57Bl/6 mice // Zbornik / Balenović, Mirta ; Wittner, Velimir (ur.).
Zagreb: Hrvatsko mikrobiološko društvo, 2004. (poster, nije recenziran, sažetak, znanstveni)
Vučković, D., Abram, M. & Dorić, M. (2004) Experimental campylobacteriosis in C57Bl/6 mice. U: Balenović, M. & Wittner, V. (ur.)Zbornik.
@article{article, author = {Vu\v{c}kovi\'{c}, Darinka and Abram, Maja and Dori\'{c}, Miljenko}, year = {2004}, pages = {170}, keywords = {Campylobacter, mice, experimental}, title = {Experimental campylobacteriosis in C57Bl/6 mice}, keyword = {Campylobacter, mice, experimental}, publisher = {Hrvatsko mikrobiolo\v{s}ko dru\v{s}tvo}, publisherplace = {Pore\v{c}, Hrvatska} }
@article{article, author = {Vu\v{c}kovi\'{c}, Darinka and Abram, Maja and Dori\'{c}, Miljenko}, year = {2004}, pages = {170}, keywords = {Campylobacter, mice, experimental}, title = {Experimental campylobacteriosis in C57Bl/6 mice}, keyword = {Campylobacter, mice, experimental}, publisher = {Hrvatsko mikrobiolo\v{s}ko dru\v{s}tvo}, publisherplace = {Pore\v{c}, Hrvatska} }




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