engleski

The Role of Insulin and IGF-1 Signaling in Longevity

There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and IGF-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.

aging; lifespan; genetic instability; telomerase; oxidative stress; superoxide dismutase

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