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Met-enkephalin and naloxone effects on head and neck squamous cell carcinoma cell lines


Kraljević, Sandra; Štambuk, Nikola; Kralj, Marijeta; Konjevoda, Paško
Met-enkephalin and naloxone effects on head and neck squamous cell carcinoma cell lines // Book of Abstracts MATH/CHEM/COMP 2004 / Graovac, Ante ; Pokrić, Biserka ; Smrečki, Vilko (ur.).
Zagreb: Institut, 2004. str. 36-36 (predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Met-enkephalin and naloxone effects on head and neck squamous cell carcinoma cell lines

Autori
Kraljević, Sandra ; Štambuk, Nikola ; Kralj, Marijeta ; Konjevoda, Paško

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts MATH/CHEM/COMP 2004 / Graovac, Ante ; Pokrić, Biserka ; Smrečki, Vilko - Zagreb : Institut, 2004, 36-36

Skup
MATH/CHEM/COMP 2004 - The 19th Dubrovnik International Course & Conference on the Interfaces among Mathematics, Chemistry and Computer Sciences

Mjesto i datum
Dubrovnik, Hrvatska, 21.-26.06.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Head; met-enkephalin; naloxone; neck; squamous cell carcinoma

Sažetak
Met-enkephalin is a neuropeptide with multifunctional properties on cell growth, division and differentiation. Its effects include in vitro and in vivo modulation of tumor cell growth via delta and/or zeta opioid receptors. We investigated the effects of met-enkephalin and naloxone (opioid receptor antagonist) on cell lines CAL-27 and Detroit-562 of the head and neck squamous cell carcinoma (HNSCC). The influence of met-enkephalin and naloxone on tumor cell lines growth was evaluated using MTT cell proliferation assay. Tested substances were applied in the range of pharmacologically relevant concentrations (10-6 to 10-3 M). Dose-response curve analysis of met-enkephalin and naloxone effects on the tumor cell growth was done by means of GraphPad Prism Software, version 4.0. We found that opioid receptor blockade was the primary mechanism of agents' negative influence on CAL-27 and Detroit-562 cell line growth.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0098092
0098097

Ustanove
Institut "Ruđer Bošković", Zagreb