Met-enkephalin and naloxone effects on head and neck squamous cell carcinoma cell lines (CROSBI ID 498071)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Kraljević, Sandra ; Štambuk, Nikola ; Kralj, Marijeta ; Konjevoda, Paško
engleski
Met-enkephalin and naloxone effects on head and neck squamous cell carcinoma cell lines
Met-enkephalin is a neuropeptide with multifunctional properties on cell growth, division and differentiation. Its effects include in vitro and in vivo modulation of tumor cell growth via delta and/or zeta opioid receptors. We investigated the effects of met-enkephalin and naloxone (opioid receptor antagonist) on cell lines CAL-27 and Detroit-562 of the head and neck squamous cell carcinoma (HNSCC). The influence of met-enkephalin and naloxone on tumor cell lines growth was evaluated using MTT cell proliferation assay. Tested substances were applied in the range of pharmacologically relevant concentrations (10-6 to 10-3 M). Dose-response curve analysis of met-enkephalin and naloxone effects on the tumor cell growth was done by means of GraphPad Prism Software, version 4.0. We found that opioid receptor blockade was the primary mechanism of agents' negative influence on CAL-27 and Detroit-562 cell line growth.
head ; met-enkephalin ; naloxone ; neck ; squamous cell carcinoma
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Podaci o prilogu
36-36.
2004.
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objavljeno
Podaci o matičnoj publikaciji
Book of Abstracts MATH/CHEM/COMP 2004
Graovac, Ante ; Pokrić, Biserka ; Smrečki, Vilko
Zagreb: Institut Ruđer Bošković
Podaci o skupu
The 19th Dubrovnik International Course and Conference on the Interfaces among Mathematics, Chemistry and Computer Sciences (MATH/CHEM/COMP '04=
predavanje
21.06.2004-26.06.2004
Dubrovnik, Hrvatska