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Sinteza i biološka aktivnost novih amidino-supstituiranih-benzimidazola i amidino-supstituiranih-benzimidazo [1, 2-a]kinolina kao hidroklorida


Hranjec, Marijana; Kralj, Marijeta; Šuman, Lidija; Pavelić, Krešimir; Karminski-Zamola, Grace
Sinteza i biološka aktivnost novih amidino-supstituiranih-benzimidazola i amidino-supstituiranih-benzimidazo [1, 2-a]kinolina kao hidroklorida // 2nd Central European Conference, Chemistry towards Biology / Kratky, Christoph ; Konrat, Robert (ur.).
Graz, 2004. str. 49-50 (poster, nije recenziran, sažetak, znanstveni)


Naslov
Sinteza i biološka aktivnost novih amidino-supstituiranih-benzimidazola i amidino-supstituiranih-benzimidazo [1, 2-a]kinolina kao hidroklorida
(SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW AMIDINO-SUBSTITUTED-BENZIMIDAZOLES AND AMIDINO-SUBSTITUTED-BENZIMIDAZO [1, 2-a]QUINOLINES AS HYDROCHLORIDE SALTS)

Autori
Hranjec, Marijana ; Kralj, Marijeta ; Šuman, Lidija ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2nd Central European Conference, Chemistry towards Biology / Kratky, Christoph ; Konrat, Robert - Graz, 2004, 49-50

Skup
2nd Central European Conference, Chemistry towards Biology

Mjesto i datum
Seggau, Austria, 26.-29.09.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Benzimidazoles; amidines; quinolines

Sažetak
Amidino substituted heterocyclic compounds exhibit antitumor activity, and serve as intercalators on DNA and inhibitors of topoisomerase II1, or as "groove binders" 2. The effects of several compounds on proliferation of different human tumor cell lines, as well as on normal (diploid) human fibroblasts (control cell line) were investigated. The experiments were carried out on the following cell lines: HeLa (cervical carcinoma), MCF-7 (breast carcinoma), SW 620 (colon carcinoma), MiaPaCa-2 (pancreatic carcinoma), Hep-2 (laryngeal carcinoma) and WI 38 (diploid fibroblasts).3, 4 All new prepared compounds had markedly differential antiproliferative activity among the panel cell lines, but interestingly, all compounds showed potent inhibitory effect on HeLa cell line. LITERATURE: 1. E. P. Vivas-Mejía et all ; Molecular and Cellular Biochemistry 1997, 177, 69. 2. C. Kus, D. W. Boykin, H. Göker ; Heterocyclic Comm. 2002, 8, 3, 215. 3. M. R. Boyd, D. P. Kenneth ; Drug Dev Res. 1995, 34, 91-109. 4. Mossman, T ; Immunol. 1983, 65, 55­63.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098092
0098093
0125005

Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb