engleski

Solvent Proton Magnetic Relaxation in Solution of Rabbit Liver Cytochrome P-450. - On the Correlation Time for the Electron Proton Dipole-Dipole Interaction

Structural parameters can be derived from PMR measurements if the correlation time for the spin interaction is known. The relaxation rates induced by the ferric haem-iron of cyt P450 were found to be frequency independent from 10 to 37 MHz. The possible limits for the correlation time according to Solomon's theory are discussed with regard to the possible existance of water molecule at sixth coordination site of the haem-iron. No definite conclusion could be reached in this respect, but the results are definitively in favour of a haem environment which can accomodate several water molecules exchanging quickly with bulk of solvent.

Cytochrom P-450; Frequency dispersion; Proton magnetic relaxation; Rabbit

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