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Pregled bibliografske jedinice broj: 153569

A Proton Magnetic Relaxation Study of Ferric Myoglobin and Haemoglobin in Water/Ethanediol Solutions


Vuk-Pavlović, Stanimir; Bračika, Vlasta; Benko, Bojan; Maričić, Siniša
A Proton Magnetic Relaxation Study of Ferric Myoglobin and Haemoglobin in Water/Ethanediol Solutions // Biochimica et Biophysica Acta. Protein Structure, 491 (1977), 2; 447-456 (međunarodna recenzija, članak, znanstveni)


Naslov
A Proton Magnetic Relaxation Study of Ferric Myoglobin and Haemoglobin in Water/Ethanediol Solutions

Autori
Vuk-Pavlović, Stanimir ; Bračika, Vlasta ; Benko, Bojan ; Maričić, Siniša

Izvornik
Biochimica et Biophysica Acta. Protein Structure (0006-3002) 491 (1977), 2; 447-456

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Haemoglobin; Inositol hexaphosphate; Mixed solvent; Myoglobin; Proton magnetic relaxation

Sažetak
Structural alterations of the haem vicinity of the high-spin derivatives of bovine ferric myoglobin (metmyoglobin) and human haemoglobin and the changes of the interaction with inositol hexaphosphate induced by ethanediol were monitored by solvent-proton magnetic relaxation. On addition of ethanediol up to 60% the fluoromet derivatives exhibit a gradual increase in the accessibility of the haem for the molecules from the solvent. In aquomethaemoglobin solutions with more than 25% ethanediol there is no unique explanation of proton magnetic relaxation. Ethanediol enhances the binding of inositol hexaphosphate to methaemoglobin, but the structural consequences of this binding on the haem-pockets seem to be diminished. The mechanisms of the observed structural and functional alterations of myoglobin as well as haemoglobin tetramer are discussed here.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biologija



POVEZANOST RADA


Ustanove
Imunološki zavod d.d.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts