engleski

Pyridinium, imidazolium, and quinucludinium oximes : synthesis, interaction with native and phosphylated cholinesterases, and antidotes against organophosphates

This report summarizes studies on pyridinium, imidazolium, and quinuclidinium oximes, which were prepared in laboratories in Croatia since the middle of the 1970s. The prepared compounds, 176 in all, include 157 new compounds. The majority of prepared compounds are monoquaternary and bisquaternary pyridinium oximes. In vitro studies comprised reversible inhibition of cholinesterases, protection of cholinesterases from phosphylation by organophosphorus compounds (OP), and reactivation of the phosphylated enzyme. In vivo studies of the oximes as antidotes in experimental poisoning by OP compounds are also reviewed. The OP compounds were predominantly chemical warfare (CW) nerve agents but also included some related pesticides.

pyridinium ; imidazolium ; quinuclidinium oximes ; organiophosphates ; cholinesterases

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