engleski

Hyperresponsiveness to tobacco dust extact in sensitized guinea pig trachea

Guinea pigs were sensitized using Ovalbumin(OA) and susequently challenged with an aerosol of 2.5% OA on day 21. A control group of nonsensitized guinea pigs were also studied. Isolated guinea pig*s trachea of sensitized animals demostrated a greater contractile response to tobbaco dust extract than did nonsensitized guinea*s trachea. The findings suggest that presensitization with an unrelated antigen enhances the response to an occupational agent.

tobacco dust extract; guinea pigs trachea

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