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Pregled bibliografske jedinice broj: 150903

Semen quality and reproductive endocrine function with regard to blood cadmium in Croatian male subject


Jurasović, Jasna; Cvitković, Petar; Pizent, Alica; Čolak, Božo; Telišman, Spomenka
Semen quality and reproductive endocrine function with regard to blood cadmium in Croatian male subject // BioMetals, 17 (2004), 6; 735-743 (međunarodna recenzija, članak, znanstveni)


Naslov
Semen quality and reproductive endocrine function with regard to blood cadmium in Croatian male subject

Autori
Jurasović, Jasna ; Cvitković, Petar ; Pizent, Alica ; Čolak, Božo ; Telišman, Spomenka

Izvornik
BioMetals (0966-0844) 17 (2004), 6; 735-743

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Human male reproductive function; nonoccupational cadmium exposure; sex hormones; smoking; toxic and essential metals interaction

Sažetak
In 123 Croatian men with no occupational exposure to metals, the influence of cadmium on reproductive parameters was examined after adjusting for age, smoking, alcohol, and biomarkers of lead, copper, zinc, and selenium. The following variables were measured: blood cadmium (BCd), blood lead (BPb), activity of delta-aminolevulinic acid dehydratase (ALAD), erythrocyte protoporphyrin, serum copper (SCu), serum zinc (SZn), serum selenium (SSe), activity of glutathione peroxidase (GPx) in blood, testis size, semen quality (including sperm concentration, motility, viability, and morphology), indicators in seminal fluid (the lactate dehydrogenase isoenzyme LDH-C4, fructose, zinc, acid phosphatase, and citric acid), and hormones in serum (follicle-stimulating hormone - FSH, luteinizing hormone, prolactin, testosterone, and estradiol). The median and range BCd values were 2.94 (0.49-11.93) microg/L in 61 smokers and 0.59 (0.20-3.71) microg/L in 62 nonsmokers (P < 0.0001). Smoking habits (cigarettes/day) highly significantly correlated with BCd (P < 0.0001). After adjusting for potential confounding variables by multiple regression, BCd was significantly associated with a decrease in testis size (P < 0.03) and an increase in serum estradiol (P < 0.005), FSH (P < 0.03), and testosterone (P < 0.04). Smoking was significantly associated with a decrease in serum prolactin (P < 0.006) and LDH-C4 in seminal fluid (P < 0.03). Several reproductive parameters were significantly associated with BPb and ALAD, biomarkers of lead, and/or with SCu, SZn, SSe, and GPx. The necessity of controlling for various metals, and other potential confounders when assessing the influence of a particular metal on reproductive function in men, is emphasized.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
0022010
0045002

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE