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Pregled bibliografske jedinice broj: 150627

Is likelihood ratio a sufficient tool to estimate confidence of a genetic match in a DNA-lead process of identification of war victims?


Džijan, Snježana; Primorac, Dragan; Marcikić, Mladen; Lauc, Gordan
Is likelihood ratio a sufficient tool to estimate confidence of a genetic match in a DNA-lead process of identification of war victims? // 13th International Meeting on Forensic Medicine Alpe-Adria-Pannonia, Abstract book
Graz, 2004. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Is likelihood ratio a sufficient tool to estimate confidence of a genetic match in a DNA-lead process of identification of war victims?

Autori
Džijan, Snježana ; Primorac, Dragan ; Marcikić, Mladen ; Lauc, Gordan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th International Meeting on Forensic Medicine Alpe-Adria-Pannonia, Abstract book / - Graz, 2004

Skup
13th International Meeting on Forensic Medicine Alpe-Adria-Pannonia

Mjesto i datum
Graz, Austria, 21-22.05.2004.

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Forensics; DNA typing; human identity

Sažetak
With the advance in typing tools and extraction procedures in the recent years, DNA analysis developed into amazingly powerful method for forensic analysis. For a number of years we are using autosomal STR typing as a tool to lead the process of identification of war victims in Croatia. Although DNA typing is very effective in finding possible identities of exhumed skeletal remains, this approach bears some risk of wrong identification. Here we report a case of a match between skeletal remains and mother, son and wife of a missing person with a cumulative likelihood ratio of nearly 2×109 that was shown to be a false match, since additional genetic testing (Y-STR and mitochondrial DNA) unequivocally excluded the proposed identity. Although we still use likelihood ratios as a main measure of the significance of a genetic match between exhumed skeletal remains and relatives of a missing person, in database matching the meaning of likelihood ratio is not as clear as in simple paternity cases and great care is needed to avoid wrong identification. In addition to DNA evidence we heavily relay on other types of evidence (such as the information about time, place and other conditions of disappearance), as well as anthropological and other "classical" forensic data as a "control mechanism" in the DNA-lead process.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0006611
0219041

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Osijek