engleski

A case of atopic dermatitis with sudden appearance of acquired ichthyosis

Acquired ichthyosis is not inherited and occurs for the first time in adulthood. It is usually associated with some general systemic disease, such as cancer (lung, breast, ovary, cervix), Hodgkin disease, lymphoma, sarcoidosis, Kaposi sarcoma, leprosy. thyroid disease, nutrition disorders, HIV infection, etc. It may be provoked by certain medications (such as nicotinic acid, hydroxyurea, cholesterol-lowering agent, cimetidine clofazimine). A 25-year old men without past history of skin disease, was admitted to our Department. Two months before he noticed hyperkeratosis on his palms and soles with a painful fissuring. Gradually, his skin becomes dry with symmetrical lamellar hyperpigmented scaling, particularly on the extensor surfaces of the extremities and lateral aspects of his trunk and back. At birth his skin appeared normal. Nobody in the family had a history of atopic diseases. Laboratory results revealed low level of vitamin A in the serum and elevated levels of IgE. Histological findings confirmed vulgar ichthyosis associated with atopic dermatitis. PRICK test was positive to many inhalant allergens. Internal diseases and malignancies were excluded. He was treated with local keratolitics and neutral ointments together with vitamin A preparations. Acquired ichthyosis is extremely rare. When it is suddenly presented in adult patient, associated internal diseases should be excluded. Recognition of these conditions is necessary to institute therapy that will reduce discomfort experienced by affected individuals.

Acquired ichthyosis; general systemic diseases; IgE; prick test; inhalant allergens

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