engleski

Expression of FasL molecule in acute and chronic psoriatic plaque

Psoriasis is autoimmune skin diseas in which keratinocyte proliferation was initiated by T cell infiltration and activation. Among T cells, CD4+ T cell predominance in exacerbated psoriatic plaques and CD8+ T cells in resolutive lesions are demonstrated. Cell mediated cytotoxicity reactions (CMC) are mediated by perforin and granzyme exocytosis or binding of FasL (CD95L) with Fas receptor (CD95) on target cell. CD8+ T lymphocytes and to a certain degree CD4+ T lymphocytes as well as NK cells mediate in CMC. The role of cytolytic Fas/FasL pathway is recognized in psoriasis but still insufficiently defined. The aim of our investigation was to analyze expression of Fas and FasL molecules in the psoriatic skin lesions and highlight a role of cytotoxicity mediated by this pathway in pathophysiology of disease.

FasL molecule; psoriasis

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